Table of contents
The effect of glutazone tablets on fatty liver
Glutazone tablets or Pioglitazone increases the body's sensitivity to insulin. In non-alcoholic fatty liver, insulin resistance is one of the main factors of fat accumulation. By consuming glutazone, liver cells can better consume glucose and the amount of accumulated fat decreases. In addition to reducing fat, glutazone can reduce liver inflammation.
Chronic inflammation caused by fat accumulation can lead to fibrosis and even liver cirrhosis, so reducing this inflammation is an important step in protecting the liver. Studies show that patients who take glutazone along with lifestyle changes have greater improvements in liver function tests and fatty liver levels than those who follow diet and exercise alone. This shows that the drug's effect is very effective along with lifestyle modification.
| Pharmaceutical ID | Description |
|---|---|
| What is Glutazone Tablet? | Oral antidiabetic medication to control blood sugar in patients with Type 2 diabetes mellitus, especially when diet and exercise alone are not enough. |
| Generic name of the drug | Pioglitazone |
| Trade name | Glutazone (also sometimes known by other names such as Actos in international markets) |
| Type of drug | Oral antidiabetic drug; From the group of thiazolidinediones (Thiazolidinediones / "glitazones") |
| Pregnancy category | According to the information, it is placed in category "C" in pregnancy; It means that it should only be used under special conditions and under the supervision of a doctor. |
| Half-life | Half-life of parent molecule: about 3-7 hours; Active metabolites (M-III and M-IV): 16–24 hours. |
| excretion of the drug | metabolized in the liver (approximately 99%); Major elimination through feces (more than 55%) and a part through urine (15-30%) in the form of metabolites. |
| Mechanism of action | Selective agonist of PPAR-γ nuclear receptor — by activating this receptor, the sensitivity of body cells to insulin increases, glucose absorption by tissues (muscle and fat) improves and new glucose production in the liver decreases. |
| Best storage conditions | Tablets should be stored at normal room temperature (usually 15-30 degrees Celsius), in closed containers, away from light, moisture and extreme heat. |
| how to use | usually once a day (depending on the doctor's prescription); It can be taken with or without food. The usual dose is 15, 30 or 45 mg, and if needed, the doctor may adjust the dose. |
| Pharmaceutical form | Oral tablet (Tablet) — usually 15, 30 or 45 mg |
| Medications of the same group | Other drugs of the thiazolidine-diones group (glitazones) — like other drugs with the active ingredient Similar. |
How to take glutazone tablets for fatty liver
Glutazone is usually taken orally and according to the doctor's prescription. The exact dosage of the drug is determined based on the severity of the disease, the patient's weight and other medical conditions. To achieve the best results, the drug should be taken regularly and at certain times of the day.
A sudden dose change or arbitrary discontinuation of fatty liver pill can reduce its effectiveness. In addition to taking medicine, it is necessary to follow a healthy diet and regular physical activity. Glutazone alone cannot cure fatty liver, but it is a therapeutic supplement along with lifestyle changes.
Glutazone side effects for fatty liver
One of the most common side effects of glutazone is weight gain. This weight gain occurs mostly due to the accumulation of fluids and sometimes increased appetite, so it is very important to control the diet when taking the drug. In addition, long-term use of glutazone can cause fluid retention, swelling of the legs, and increased risk of heart failure.Patients with a history of heart disease should be closely monitored by a doctor. Less common side effects include changes in liver function, headache, muscle pain, and in rare cases, bone problems. There are reports of decreased bone density and increased fracture risk in the long term, especially in older women.
English text:
quoted from the site ncbi.nlm.nih
The common adverse effects of pioglitazone are edema, weight gain, macular edema, osteoporosis, and congestive heart failure (CHF).
Persian translation:
Common adverse effects of pioglitazone include edema, weight gain, macular edema, osteoporosis, and congestive heart failure (CHF).
Precautions and contraindications of glutazone tablets for fatty liver
People who have heart, liver or kidney diseases should consult their doctor before starting to use glutazone. Arbitrarily taking medicine can be dangerous and worsen the condition of the disease. Patients with high blood pressure or fluid retention problems should regularly monitor their blood pressure and weight to prevent serious complications.
Also, those who have a history of bone fractures or are subject to a decrease in bone density, should take care while taking the drug and take calcium and vitamin D supplements if needed.
taking glutazone tablets for fatty liver in pregnancy
Glutazone use is not recommended during pregnancy. There are not enough studies on the safety of the drug for the fetus and unwanted side effects may occur. Pregnant women should definitely consult their doctor about alternative treatment fatty liver in pregnancy.
English text:
Quoted from medlineplus
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pioglitazone, call your doctor. Do not breast-feed while you are taking pioglitazone.
Persian translation:
Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding your baby. If you become pregnant while taking pioglitazone (glutazone), call your doctor. Avoid breastfeeding while taking pioglitazone.
taking glutazone tablets for fatty liver in breastfeeding
The use of glutazone during breastfeeding is also limited. The drug may pass into breast milk and affect the baby. If the use is necessary, the doctor must decide whether the drug can be used in a low dose and under supervision or if breastfeeding needs to be stopped.
Conclusion
Glutazone can be an effective tool in controlling fatty liver, provided that it is consumed along with a healthy lifestyle and under the supervision of a doctor. This medicine helps to reduce fat and liver inflammation and slows down the disease process. However, the use of glutazone tablets for fatty liver requires regular follow-up and attention to side effects. Patients should check their blood pressure, weight and liver function and consult a doctor if abnormal symptoms occur. Finally, glutazone is a complementary therapy and does not replace a proper diet and regular exercise. Visiting the doctor regularly and performing periodical tests is the best way to use this medicine safely and effectively.
Your doctor takes care of your health!
