The best knee pain pill depends on the type of pain in different parts of the knee, including the bones, cartilages or muscles around it, different medicine is needed. The treatment of knee pain is very different depending on its cause, and choosing the best pill and drug for knee pain requires accurate diagnosis by a doctor. In general, anti-inflammatory steroid drugs NSAIDS and painkillers such as ibuprofen and drugs that reduce pressure on the nerve and reduce inflammation such as naproxen can be considered the best knee pain pills to reduce pressure on the knee nerves. However, some common medications that may be prescribed as the best knee pain pills for knee pain relief include: **1.** **Nonsteroidal anti-inflammatory drugs (NSAIDs)**: Drugs such as ibuprofen (such as Advil or Motrin) and naproxen (Alio) can be used to reduce inflammation and relieve pain. **2.** **Acetaminophen (Tylenol)**: For mild to moderate pain, acetaminophen can be a good option. Although it does not reduce inflammation, it can be effective in relieving pain. **3. Topical creams and gels**: Products containing capsaicin or anti-inflammatory agents such as diclofenac may be helpful for some people. **4.** **Steroid injection**: In cases where pain is caused by inflammation, corticosteroid injection can reduce inflammation and pain for a while. **5.** **Supplements**: Some people use supplements such as glucosamine and chondroitin, MSM or curcumin to relieve knee pain. Although studies have shown mixed results, some people benefit from their use. Before starting any type of treatment, it is important to consult with your doctor to determine the best option based on your specific situation. Also, some non-drug treatments such as physical therapy, weight loss if necessary, and strengthening exercises may help relieve knee pain. ***Learn more: When is knee replacement needed?**