What is prolactin hormone? ====================== Prolactin hormone is secreted by the lactotroph cells in the anterior part of the pituitary gland. However, it is also produced in the decidua of the pregnant uterus, uterine myometrium, breast, white blood cells and prostate. #### **Hyperprolactomy: (increased PRL)** Hyperprolactomy is a common problem that has many causes. This disease is more common in women, but it also occurs in men even at younger ages. **Causes of hyperprolactomy:** Sleep disorders, nutritional problems, pain and stress, sexual intercourse, pregnancy, breast irritation, breastfeeding. Systemic diseases, lesions of the chest or spine in the back area, primary or secondary hypothyroidism. Adrenal gland failure, chronic kidney failure, liver cirrhosis and polycystic ovary syndrome. **Medicine:** Anti-depressants such as phenothiazines, haloperidol, thioxanthines, buspirone, monoamine oxidase inhibitors. Fluoxetine, amitriptyline, methoclopramide, **antihypertensive drug** labetolol, alpha methyldopa, reserpine, verapamine. Cimetidine, estrogens, **contraceptive pills** (during use or after stopping), **opium derivatives**, heroin, morphine and methadone. **Clinical signs of hyperprolactinemia:** 1- Increased prolactin in the blood: Increased prolactin in the blood causes amenorrhea, galactorrhea, lack of sexual hair. Hypogonadism (hypogonadism), gynecomastia (breast enlargement in men) and impotence and spermatogenesis disorder (sperm production in men). 2- The effects of prolactinoma mass increase: include visual impairment, headache, dizziness, nausea and vomiting. **The use of drugs is one of the common causes of hyperprolactinemia, and one of its other causes is hypothyroidism.** **Usually, hyperprolactinemia patients come with symptoms of irregular menstrual cycle or infertility.** **And they are treated by gynecologists.**