One of the main causes of male infertility, which usually does not show any specific symptoms, is azoospermia or zero sperm. In this case, no sperm can be found in the man's seminal fluid, which can be due to the absence of sperm in the testicles, disorders related to hormones and glands before the testicles, or obstruction in the path of sperm transfer after the testicles. Azoospermia is the cause of 15% of male infertility and about 1% of men. In some cases, zero sperm may also be due to obstructive disorders. In such a situation, testicular biopsy is proposed as one of the ways to treat zero sperm. By using different testicular sampling methods, the infertility treatment doctor can find the sperm and perform assisted reproductive methods such as IVF and microinjection.

What is **Azoospermia**? Azoospermia is the absence of sperm in men's semen. In this case, no sperm are found in the man's semen. Azoospermia can occur due to various reasons, including disorders related to hormones and glands before the testis, disorders related to the testis and the process of sperm production, or obstruction in the path of sperm transfer after the testis. Azoospermia is one of the main causes of male infertility and usually does not show any specific symptoms. If no sperm is found in the man's semen, it is impossible to get pregnant naturally. In some cases, the cause of azoospermia is related to obstructive disorders, which may improve with testicular biopsy or other treatment methods. In the absence of effective sperm for fertility, assisted reproductive methods and **infertility treatment** such as IVF and microinjection are used. ### **cause of azoospermia** The cause of azoospermia can be related to hormonal disorders and glands, and in these cases, treatment of hormonal disorders can help you improve sperm and get pregnant. Also, in some cases, the cause of azoospermia can be related to external factors such as the use of drugs affecting sperm, drugs, tobacco, alcohol, or environmental factors. In these cases, lifestyle changes and prevention factors such as healthy eating and health care can help you improve sperm quality and get pregnant.

**Is pregnancy possible with zero sperm?** According to the causes and type of azoospermia, in many cases it is possible to carry out appropriate treatment despite having zero sperm and get the chance to have a child. In case of insufficient growth and small testicles, hormone therapy can increase the chance of fertility with a success rate of up to 95%. In people with testicular varices or varicocele, surgery can significantly increase the chance of fertility. It should be noted that subcutaneous embolization can be used to treat varicocele. Also, if there is an obstruction in the way of sperm transfer, surgery can strongly restore fertility, and techniques such as IUI and **pregnancy with IVF** can be used to treat infertility and the wife's pregnancy. In general, the treatment of azoospermia and fertility with zero sperm is complicated due to the various causes that may be related to it, and requires consultation and treatment by a doctor specializing in infertility treatment. By characterizing the problem of zero sperm and accurately diagnosing its cause, the doctor can determine the appropriate treatment methods for you. Also, to increase the chances of fertility, you can take advantage of lifestyle changes such as eating healthy, eliminating stress, and reducing alcohol and tobacco consumption.

** ways to detect zero sperm** To detect zero sperm, various methods are used, such as physical examinations and taking the patient's history, measuring blood hormones, ultrasound of the ejaculatory system, ultrasound of the urinary system, sampling from the testicle, measuring the amount of sugar in the semen, genetic tests such as the Y chromosome analysis test and karyotype test. After several months of trying to have a child and the wife not being pregnant, the doctor usually receives a sample of semen, examines it under a microscope, and if no sperm is seen, he looks for the cause. The doctor can diagnose the cause of zero sperm by using physical examinations, sperm analysis test, Y chromosome break test, hormonal tests, testicular biopsy and post ejaculation urine test. If the infertility problem is from the woman's side, egg freezing is one of the ways to improve the fertility process. If you want to know more about this treatment, you can read this article: **egg freezing**

**What are the ways to treat zero sperm?** The treatment of zero sperm depends on the cause. By accurately diagnosing the cause of zero sperm, the doctor can determine the appropriate treatment methods for you. Below are the methods used to treat zero sperm: 1. Hormonal treatment: If the cause of zero sperm is due to a lack of male hormones such as testosterone, hormonal treatment is used to restore the level of hormones to normal and increase sperm production. 2. Surgery: In some cases, you need surgery to prevent blockage or no sperm production. For example, if the patient has a varicocele (swelling and knots in the veins of the testicle), surgery to remove the swollen veins can improve the condition. 3. Drug treatment: Some drugs such as human chorionic gonadotropin (hCG) and dopamine use can improve sperm production in some cases. 4. Use of technology related to fertility: Methods such as artificial insemination and some new technologies such as sperm freezing (Sperm Cryopreservation) and their re-injection (Intracytoplasmic Sperm Injection) can also improve fertility conditions in some cases. 5. Lifestyle changes: In order to increase the chances of fertility, you can take advantage of lifestyle changes such as eating healthy, eliminating stress, and reducing alcohol and tobacco consumption.