تزریق فیلرهای پوستی، تزریق بوتاکس و تزریق ژل گونه به عنوان یکی از پرطرفدارترین روش های جوان سازی و زیبایی، نتایج موقتی دارند که بسته به عوامل متعددی می تواند از چند ماه تا بیش از یک سال دوام داشته باشد. But is the subject the effect of metabolism on the durability of fillers real?!
One of the most important and less important factors is the role of the body's metabolism in the amount of absorption and durability of fillers. This article from the site Dr. Behzad Farrokhi deals with a detailed and scientific study of the effect of metabolic rate on the lifespan of fillers and analyzes the key effective factors.
What is the meaning of the high metabolism and who includes it?
Metabolism refers to the set of chemical reactions in the body that are responsible for providing energy for vital functions. This process includes two main parts: catabolism (breakdown of substances) and anabolism (building new compounds).People who have a higher metabolic rate consume more energy and their body metabolizes and absorbs injectable substances like fillers more quickly. This issue can have a direct effect on reducing the shelf life of fillers.
How does fast metabolism cause fillers to break down faster?
Fillers, especially hyaluronic acid types, are broken down over time by body enzymes such as hyaluronidase. In people with a fast metabolism, this breakdown process occurs faster because:
- Blood flow is more on the surface of the skin.
- Decomposing enzymes are more active.
- The tissue repair and regeneration process is done at a higher speed.
As a result, the durability of the filler in these people may be significantly less than in people with a lower metabolism.
factors influencing metabolism and durability of filler
Metabolism is affected by a set of factors, each of which can indirectly affect the durability of fillers.
| Factor | Effect on metabolism | Effect on filler durability |
| Age | With age, metabolism decreases | Increasing filler durability |
| Activity Physical | Increased activity increases metabolism | Decreases filler durability |
| Environmental temperature | Warmer environment increases metabolism | Decreases filler durability |
| Genetics | Some people naturally have a higher metabolism have | natural decrease in shelf life |
| diet | consumption of protein and stimulants such as caffeine increase metabolism | faster breakdown of fillers |

What types of fillers are more resistant to metabolism?
All fillers are gradually absorbed and broken down by the body; But the chemical structure, density and the way the molecules inside the filler are connected determine how long they resist the enzymes and metabolic processes of the body. In general, fillers with more cross-linking are slower to degrade and are more resistant to degrading enzymes such as hyaluronidase.
Category of metabolism-resistant fillers:
| Type of filler | Main composition | Permanence rate | Feature of resistance to metabolism |
| Radiesse | Calcium hydroxyapatite | About 12-18 Moon | Mineral microsphere structure, high resistance |
| Ellansé | Polycaprolactone (PCL) | 1 to 4 years depending on the model | Stimulation of collagen formation and high metabolic stability |
| Juvederm Voluma / Volux | Cross-linked hyaluronic acid High | 12-18 months | High concentration and network resistant to decomposition |
| Sculptra | Poly L-lactic acid | About 2 years | Stimulation of collagen formation, gradual and resistant performance |
Scientific tip: Hyaluronic acid (HA) fillers are usually absorbed faster; But brands that use high cross-linking technology such as Vycross (such as Juvederm Voluma) show more resistance.
solutions to increase the durability of filler in people with high metabolism
People with a high metabolism (such as athletes, young people, or people with a mesomorph or ectomorph body type) usually absorb fillers faster. However, by following some scientific and specialized solutions, the shelf life of the filler can be increased and the results of the injection can be benefited the most.
- Using slow-absorbing or stronger fillers
- Avoid vigorous physical activity during the first 72 hours after injection
- Less consumption of stimulants such as caffeine and alcohol
- Suitable hydration for the skin
- Do periodic repairs (Touch-up)

Effective tips to increase the durability of filler
Note that some doctors prefer the use of collagen-forming fillers for people with high metabolism, because these fillers stimulate the production of natural collagen and leave a more lasting effect, even if they break down initially.
1. Choosing the right filler
- Using long-lasting fillers such as Ellansé or Radiesse
- choice of filler with high concentration and strong cross-link technology
2. Post-injection care
- Abstaining from heavy sports and heavy sweating for 3 to 5 days
- Avoid alcohol, caffeine and tobacco that increase the rate of metabolism.
- Using a cold compress in the early hours (if prescribed by a doctor) to reduce inflammation and local activity of enzymes
3. Balanced lifestyle
- Maintaining an anti-inflammatory diet (using fruits and vegetables)
- Enough sleep to reduce immune system stress
- Drink enough water to support the connective tissue
4. Complementary and restorative injections (Touch-Up)
- Planning restorative injections 6 to 9 months after the initial injection to maintain shape and volume
- Regular consultation with a doctor to assess the amount of filler absorption and determine the time of re-injection
Why do some people absorb filler faster?
The injection of skin fillers (in areas such as cheeks, lips, under the eyes, etc.) is one of the most common methods of facial rejuvenation and shaping today. However, the experience of many people shows that the durability of fillers is not the same for everyone. Two people with the same brand of filler and the same volume may see different results in how long the volume and shape remain.
One of the main factors of this difference is the body's metabolism; That is, the cell metabolism that determines how quickly the body breaks down and expels substances.
What people usually have a high metabolism?
- Professional athletes or those who have high physical activity.
- People with ectomorph or mesomorph body type
- Slim people with low fat tissue
- Those who have low-calorie and high-protein diets.
- Young people, especially between the ages of 20 and 30
What factors affect the durability of the filler?
Beyond metabolism, several factors affect the durability of fillers in the body. It is important to check all these factors when injecting filler.
- The type and brand of filler (such as Juviderm, Alance, Radis)
- Filler molecular cross-linking
- Injected areas (lips, cheeks, jaw, etc.)
- lifestyle (sleep, diet, exercise)
- Movement of facial muscles
- The amount of hyaluronidase enzyme in a person's body
- Tobacco and alcohol consumption
On average, hyaluronic acid fillers last between 6 and 18 months; But in the body of people with high metabolism, they may remain for only 3 to 9 months.
Is increasing the dose of filler a proper solution?
It is sometimes thought that to overcome the effect of metabolism on the durability of the filler, injecting a larger amount of filler can have a longer effect, but this strategy may have risks, such as:
- Swelling or unevenness in the face
- increasing the possibility of filler displacement
- Decreasing the naturalness of facial appearance
A better solution is to use high quality filler and regular and controlled injections, not a large dose at once.
Frequently asked questions about the effect of metabolism on the durability of filler
In the following, some of the most common user questions are answered that may be helpful for you. If you have more questions; You can benefit from free consultation through the numbers of the site.
Does the diet have an effect on the durability of the filler?
Yes. Low-calorie or high-protein diets increase metabolism and faster absorption of fillers.
Is exercise after filler injection harmful?
In the early days, yes. Especially sports with high sweating that increase blood circulation.
Are the fillers that make collagen better?
Yes, because their effect is two-stage; Both initial volumization and stimulation of collagen production in the following months.
last word
High metabolism is a sign of health and proper activity of the body; But in the field of injecting fillers, it can create challenges for the durability of the results. By choosing the right type of filler, observing post-injection care and consulting with a specialist doctor, the effect of metabolism can be controlled to a great extent and more favorable and lasting results can be obtained.



