Topiramate tablet (topiramate) is an anticonvulsant drug (antiepileptic) that is used to treat all types of seizures. This drug is used to treat focal seizures from a specific area of ​​the brain or primary generalized tonic-clonic seizures in adults and children over 2 years old. href="https://gcorp.cc/">GCORP LLC We review the uses of this drug, side effects and how to use it.

Topiramate tablet certificate information

You can see the information and details of topiramate medicine in the table below:

What is topiramate 100 tablets for?

Topiramate is an anti-epileptic drug that is used to treat epilepsy and prevent migraine... This drug helps to restore the normal balance of nerve function by reducing abnormal electrical activity in the brain... Keep in mind that this drug can only be obtained with a doctor's prescription and is available in different forms such as tablets, capsules, and oral syrup... In the rest of this article, you can learn about other uses of this drug.

Topiramate tablets for migraine

Topiramate is approved for the prevention of episodic migraines (headaches that occur less than 15 days per month), although the exact mechanism of action is not fully understood.. But it is believed that this drug works by reducing the excitability of nerve cells by blocking sodium channels, increasing the activity of GABA (an inhibitory chemical in the brain) and reducing neuroinflammation.

The results of large, placebo-controlled studies show that topiramate can significantly reduce the number of migraine attacks, headache days, and the need for painkillers.

Topiramate 50 tablets for weight loss

Topiramate tablets have not been approved by the FDA (US Food and Drug Administration) alone for appetite suppression and weight loss. However, the combination of topiramate and phentermine is one of the few medications approved by the FDA for long-term weight management in obese or overweight people with underlying problems such as diabetes or high blood pressure.

Phentermine works by reducing appetite and stimulating the sympathetic nervous system, while topiramate helps to reduce appetite, affect the taste of food, and regulate brain metabolism. Be careful, taking topiramate 100 tablets for weight loss may cause side effects such as dry mouth, insomnia, dizziness, constipation, and increased heart rate. So avoid using them arbitrarily.

topiramate tablets for headache

Topiramate is a drug that can be effective in reducing and preventing the occurrence of some types of headaches... This drug helps to control the abnormal activity of nerve cells by methods such as blocking sodium and calcium channels, strengthening the inhibitory effect of GABA, and reducing the activity of excitatory glutamate receptors... Keep in mind that the use of this drug must be done under the supervision of a neurologist... so avoid using it arbitrarily.

Topiramate tablets for sleep

Topiramate is not officially approved to treat insomnia or improve sleep.. but it has been used informally in some specific cases, such as sleep-related eating disorders (SRED) and nocturnal eating syndrome (NES), and has been shown to reduce night eating, improve sleep, and even help with weight loss.

But the scientific evidence in this field is limited and the use of this drug may cause drowsiness, cognitive disorders and even sleep walking.

The effect of topiramate tablets on menstruation

Topiramate is not used directly to treat menstrual problems, but it can reduce the number of migraines that occur during menstruation.

In some people, topiramate may cause changes such as irregular periods, spotting or changes during the menstrual period... Also, this drug can reduce the effect of birth control pills containing estrogen and thus cause hormonal changes... Therefore, we recommend that you consult a gynecologist before taking this drug.

How to take topiramate tablets

When taking this medicine, pay attention to the following points:

• Topiramate should usually be taken twice a day.
• It can be used at any time of the day, but the time of use must be fixed every day.
• The best time to take topiramate tablets is in the morning and evening so that the interval between the doses is the same and regular.
• You can take this pill with or without food.
• Swallow the tablet or capsule completely with a glass of water and do not chew it.
• For children, the capsule can be opened and the contents poured onto a soft spoon such as porridge or yogurt.
• If you miss a dose, take it as soon as you remember.
• If it is less than 8 hours until the next dose, do not take the missed dose and do not double the next dose.
• Be aware that taking more than the prescribed amount can cause serious side effects.
• To control epilepsy, it is usually necessary to continue taking topiramate for several years.
• If you are taking this medication for migraines, you may be able to stop taking it after 6 to 12 months under your doctor's supervision.

The best time to take topiramate tablets for weight loss

Topiramate tablets can be taken at any time of the day.. but to better maintain its effects, we recommend that the time of its use be fixed.... The interval between 2 doses should be regular and almost equal.. For example, take one dose in the morning after waking up and another dose in the evening or at night. This drug can be used with or without food. Keep in mind that the effect of topiramate tablets in losing weight is revealed by the loss of appetite and must be taken under the supervision and prescription of a doctor.

Aria 25 topiramate side effects

Some of the most common side effects of this drug are:

• Dizziness, drowsiness, fatigue, slow reactions
• Speech or memory problems, visual impairment
Numbness or tingling in the hands and feet, loss of sensation especially in the skin
• Change in sense of taste, feeling anxious
• Nausea, diarrhea, stomach pain, loss of appetite
• Fever and weight loss
• Cold symptoms such as stuffy nose, sneezing or sore throat

Go to the emergency room right away if you have any signs of an allergic reaction, such as hives, shortness of breath, swelling of the face or throat, fever, sore throat, burning eyes, skin pain, a red or purple rash with blisters and crusting. Also, if you have sudden or new changes in mood, anxiety, agitation, or more severe behavior.. irritability, aggression, restlessness, talkativeness, or suicidal thoughts, report this right away. Tell your doctor.

Side effects of topiramate tablets in children

The most common side effects of this medicine in children are:

• Headache
• Difficulty concentrating
• dizziness
• fatigue
• Mood changes
• Anxiety and depression
• Decreased appetite
• Nausea
• Weight loss

Also, children may experience slowness in thinking and speaking, which is usually resolved by reducing the dose or stopping the medication... If you notice any of these side effects, see your doctor right away.

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Does this pill cause hair loss?

Research has shown that topiramate can cause hair loss (alopecia), but this complication is not common. Hair loss in children aged 6 to 16 has been reported to be about 1 to 4% and in people over 16 years old, about 3 to 4%... Also, higher doses of the drug increase the possibility of hair loss... Note that hair loss is also seen in other anti-epileptic drugs and may affect the appearance and mood of patients.

Precautions before use or Contraindications

Before taking this medicine, pay attention to the following points:

• Topiramate may cause vision problems that, if not treated quickly, can lead to permanent vision problems. If you experience sudden vision loss, call your doctor right away.
• Topiramate may cause drowsiness, dizziness, impaired concentration, tremors, loss of appetite and nausea at the beginning of use, which usually decreases with continued treatment.
• Topiramate tablets can increase body temperature and decrease sweating, which can lead to dehydration... Tell your doctor if you have decreased sweating, high fever, or hot, dry skin.
• Some people experience suicidal thoughts when taking anticonvulsants such as topiramate, sodium valproate, lamotrigine, pregabalin, and carbamazepine... Be aware of changes in your mood or symptoms and report any new or worsening symptoms to your doctor.
• Avoid stopping the medicine suddenly.. because your seizures may increase.
• Excessive use of topiramate tablets can cause coma, confusion, drowsiness and convulsions.
• The interaction of topiramate tablets with alcohol can intensify side effects and increase the risk of neurological problems or loss of consciousness. Therefore, you should not drink alcohol while taking this medicine.
Taking topiramate during pregnancy may increase the risk of cleft palate in the fetus.. If you become pregnant while taking this medicine, inform your doctor immediately..
• Topiramate can reduce the effectiveness of birth control pills.. Therefore, we recommend that you consult a gynecologist and obstetrician about other methods of contraception.
• It may not be safe to breastfeed while taking this medicine.... Consult your doctor about possible risks.

Drug interactions of topiramate

Keep in mind that taking topiramate with other drugs that cause drowsiness can increase its effect. Therefore, consult your doctor before taking narcotic drugs (opiates), sleeping drugs such as amitriptyline, muscle relaxants, or anti-anxiety and antidepressant drugs. Drugs that interact with topiramate include:

• Abilify (Aripiprazole)
• Benadryl (Diphenhydramine)
• Cymbalta (Duloxetine)
• Flexeril (cyclobenzaprine)
• Lexapro (Escitalopram)
• Lyrica (Pregabalin)
• Norco (acetaminophen/hydrocodone)
• Prozac (fluoxetine)
• Seroquel (Quetiapine)
• Xanax (alprazolam)

Remember that propranolol is a beta-blocker drug used primarily to control blood pressure, slow heart rate, and treat certain heart and anxiety disorders...this drug is not usually sedating...but it can cause fatigue and dizziness.

The simultaneous use of propranolol with topiramate usually does not cause serious drug interactions.. But both drugs can increase the effects of dizziness, drowsiness and lowering blood pressure.. Therefore, if you take these 2 drugs at the same time, you should be under the supervision of a doctor and pay attention to your body symptoms.

Drug interactions in the body

Epilepsy is a type of disorder in which abnormal and uncontrollable electrical discharges occur in the brain and cause a temporary disruption in brain function that manifests as decreased consciousness, abnormal feelings, or involuntary movements.

Topiramate drug reduces the excitability of neurons by increasing the inhibitory activity of GABA receptors and decreasing the excitatory activity of glutamate receptors and prevents epileptic and migraine attacks... Also, this drug blocks voltage-dependent sodium channels, which helps to better control attacks.>

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Remove the effect of topiramate tablets

Eliminating the effect of topiramate in the body is different depending on how this drug is used.... If the drug has been used for a long time, the body gradually gets used to it and it is not possible to eliminate it quickly.... Therefore, to reduce the effects of the drug, it should be stopped gradually and under the supervision of a doctor so that you do not suffer from seizures or sudden complications.

If the drug has been taken incorrectly or with a high dose (acute poisoning), you should go to the emergency room immediately... In this situation, gastric lavage such as gastric lavage or the use of activated charcoal in the early hours is very important to prevent further absorption of the drug. Also, supportive treatments such as providing adequate fluids, controlling symptoms such as seizures or confusion, and in severe cases dialysis may be dangerous.

diseases related to topiramate tablets

The use of topiramate in people suffering from the following diseases should be done with caution and under the supervision of a doctor in order to control the complications and exacerbation of the diseases.

• Bone problems such as osteoporosis, soft bones and decreased bone density
• Depression or its previous history
• Eye or vision problems such as glaucoma
• You suffer from mood disorders such as bipolar disorder
• Metabolic acidosis (high amount of acid in the blood) or its history
• diarrhea
• Pulmonary or respiratory problems
• status epilepticus (long-term seizure)
Kidney disease
• Liver disease
• Patients under hemodialysis treatment

Does topiramate tablets cause obesity?

Topiramate has no effect on weight gain.. Rather, one of its common side effects is weight loss... This drug usually causes a decrease in appetite, metabolic changes and weight loss.... Therefore, the use of topiramate for obesity is neither recommended nor effective.

Physician's Guide

Topiramate tablets are an effective and well-known medicine for the treatment of all types of seizures and migraine prevention, which helps to improve the condition of patients through various mechanisms such as reducing the abnormal electrical activity of the brain and regulating the function of neurochemicals... In addition to the main uses, Topiramate 25 tablets are also used in a limited way and under the supervision of a doctor for weight loss and the treatment of some sleep disorders. The drug and the importance of controlling side effects and drug interactions, it is recommended that users of this drug be under the supervision and expert advice of a neurologist in order to achieve the best treatment results and minimize possible risks. Also, in case of any new complications or changes in health status, you should immediately consult your doctor or you can consult a neurologist by referring to the GCORP website. LLC Make an appointment in person or online from the best neurologists throughout Iran.

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