Pregabalin with Lyrica brand and Gabapentin with 2 brands Neurontin and Gralis are in the category of important drugs with high effectiveness for the treatment of seizures and nerve pain.. But after comparing Pregabalin tablets with Gabapentin, we realize that these 2 drugs have the same effectiveness mechanism, side effects and chemical, but they have similar side effects.. In this article from the magazine GCORP LLC, join us to introduce you to the most important difference between pregabalin and gabapentin tablets.

Comparison of pregabalin tablets with gabapentin in terms of chemical structure

The first difference between pregabalin and gabapentin can be found in their chemical structure... these 2 tablets are classified as anticonvulsants in terms of their pharmaceutical composition, but their chemical and molecular structures are different.

• Pregabalin: This pill has a different chemical structure than gabapentin and binds to voltage-gated calcium channels in the central nervous system...this process helps reduce the release of certain neurotransmitters.. Therefore, it can reduce nerve pain and seizures.
• Gabapentin: Gabapentin binds to voltage-gated calcium channels in the nervous system, but binds to these channels differently than pregabalin and may interfere with other processes, including binding to certain proteins in the brain.

Learn more:What is Pregabalin Tablets?

What is the difference between pregabalin and gabapentin tablets in terms of effectiveness and how it works?

After comparing pregabalin tablets with gabapentin, researchers have come to the conclusion that these 2 drugs help reduce nerve activity, but they have slight differences in the level of effectiveness and how they work. The most important difference between pregabalin tablets and gabapentin in terms of effectiveness and mechanism of action is as follows:

• Pregabalin: This drug usually works faster and is often used in lower doses than gabapentin.. In fact, pregabalin prevents calcium from entering nerve cells..
• Gabapentin: This pill may need more time to reach its maximum effect and is usually prescribed in higher doses. Gabapentin works similarly to pregabalin and reduces the release of excitatory neurotransmitters by reducing the entry of calcium into neurons.

Although both drugs bind to the alpha-2 subunit of calcium channels, pregabalin seems to do this more effectively due to stronger and more stable binding... In general, it can be said that the mechanism of action of both drugs is similar to each other, but the pharmacological difference in the absorption, distribution and effectiveness of these drugs may affect their efficacy and tolerance.

Comparison of the use of pregabalin tablets with gabapentin

Comparing pregabalin tablets with gabapentin, we must say that both of them are effective drugs for the treatment of seizures and nerve pain after shingles..

It should be noted that these 2 drugs are prescribed for children, but pregabalin tablets are specifically approved for the treatment of mild seizures in children over one month of age. Also, the US Food and Drug Administration (FDA) has approved pregabalin tablets for the treatment of:

• Nerve pain caused by diabetic neuropathy
• Chronic nerve pain caused by spinal cord injury
• Fibromyalgia
• Off-label generalized anxiety disorder

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What is the difference between pregabalin and gabapentin tablets in terms of dosage?

Pregabalin and Gabapentin have a significant difference in terms of dosage, which is due to their difference in the effectiveness and pharmacology of these two drugs..

The doctor usually chooses the appropriate dose based on the age, type and severity of the disease or the history of other diseases such as kidney problems..... Currently, pregabalin tablets are available in pharmacies in doses of 25, 50, 75, 100, 150, 200, 225 and 300 mg and gabapentin tablets in doses of 100, 300 and 400 mg.

It is interesting to know, after comparing pregabalin tablets with gabapentin, researchers found that pregabalin is more powerful.. so it is usually prescribed in lower doses.... Although there is no direct dose conversion for these 2 pills, some studies have shown that every sixth dose of pregabalin can be considered equivalent to one dose of gabapentin..

Of course, it should be noted that under no circumstances should you change the dose of pregabalin and gabapentin together without consulting your doctor. It is also better to avoid stopping these drugs arbitrarily.

Learn more:What is gabapentin pill?

Comparison of side effects of pregabalin with gabapentin

Some side effects such as dizziness, mild drowsiness, confusion, diarrhea, weight gain, constipation, fatigue, impaired memory and concentration are common between these two drugs.. However, some possible side effects should be considered the difference between pregabalin and gabapentin tablets, which are:

Specific side effects of pregabalin

• vision problems
• Illusion
dry mouth
• Blurred vision
• Loss of balance and lack of coordination between body parts
• Swelling of hands and feet
• heart failure
• Rhabdomyolysis (destruction of muscles)

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Specific side effects of gabapentin

• Nausea and vomiting
• Fever
• stomach pain
• Mood changes
• email rush
• Involuntary muscle movements
• Sleep disorder
• Behavioral changes in children such as aggression and restlessness

pregabalin or gabapentin is better?

Choosing the best drug depends on the specific conditions of the patient, the response to treatment and the body's tolerance to possible side effects.. Based on the medical history, drugs used, pain intensity and other factors, the doctor chooses one of the pregabalin or gabapentin tablets with the appropriate dose for the patient..

In some cases, the doctor may prescribe gabapentin instead of pregabalin or vice versa... This transfer should be done gradually and under the doctor's supervision to avoid the side effects of stopping the drug such as seizures, anxiety, headache, diarrhea and sleep disorders..

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Usually, when changing these 2 tablets, the general practitioner will change the dose of the drug several times to achieve the desired effect... because the pregabalin tablet has a faster and better absorption.

A brief look at the comparison of pregabalin tablets with gabapentin

Pregabalin and gabapentin tablets are prescribed for the treatment of seizures and nerve pain.. These 2 drugs have a similar mechanism of action, but they differ significantly in terms of chemical composition, effectiveness, dosage and side effects.. In this article from GCORP LLC magazine, we compared pregabalin tablets with gabapentin.>

If you have any questions about how to use or the effectiveness of gabapentin and pregabalin drugs, you can visit the GCORP LLC website and get advice from the best doctors specializing in this collection.. Also, GCORP LLC provides you with the possibility to see a doctor through the online consultation system or face-to-face appointment.. Online GP consultation.. It's your turn.

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Sources: ncbi | Very good medicines for health