Table of Contents

• What is acquired lipodystrophy disorder?
  • Types of acquired lipodystrophy
    • 1....acquired general lipodystrophy (AGL)
    • 2....acquired partial lipodystrophy (APL) caused by active antiviral Top
    • (LD-HIV)
    • 4... Localized lipodystrophy
• Symptoms of acquired lipodystrophy
  • Symptoms of acquired generalized lipodystrophy
  • Symptoms of acquired partial lipodystrophy Acquired
  • active acquired antilipodystrophy
  • acquired lipodystrophy symptoms treatment
  • localized lipodystrophy symptoms
• acquired lipodystrophy causes
  • general lipodystrophy causes Acquired
  • Causes of partial acquired lipodystrophy
  • Causes of acquired lipodystrophy
  • Causes of acquired lipodystrophyCauses of highly active lipodystrophy Localized lipodystrophy
• Diagnosis of lipodystrophy Acquired
• Treatment of acquired lipodystrophy
• Prevention of acquired lipodystrophy disorder
• Frequently asked questions
  • Final words

  What is acquired lipodystrophy?

  You have fatty tissue all over your body, including under the skin and around your internal organs.... Adipose tissue has many important functions, including:

  • Energy storage in the body
  • Creating cushions for different parts of the body
  • Keeping the body warm
  • secretion of some hormones such as leptin
  • Inflammation control

  Loss of fat tissue or its abnormal distribution in the body due to lipodystrophy can cause significant changes in your appearance and affect important metabolic functions.

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  Types of acquired lipodystrophy

  There are different types of lipodystrophy that can be divided into two main categories: genetic and acquired. Since this article is dedicated to acquired lipodystrophy disorder, we introduce its different types:

  1.... Acquired generalized lipodystrophy (AGL)

  Acquired generalized lipodystrophy or "Lawrence syndrome" usually results in fat loss in the face, neck, arms, and legs that may occur rapidly over weeks or slowly over months or even years. AGL often develops in childhood or adolescence, but it can also affect adults for several reasons.

  2... Acquired partial lipodystrophy (APL)

  Acquired partial lipodystrophy, also called Barracer-Simons syndrome, is characterized by a gradual loss of fat in the face, neck, arms, and chest during childhood. Some people with APL may have extra fat around their abdomen, legs, or buttocks. APL is often associated with autoimmune problems.>

  AGL and APL both affect girls three times more often than boys, and both cause loss of facial fat, making the affected person appear older than their age or sickly.

  3... lipodystrophy caused by highly active antiretroviral therapy (LD-HIV)

  People infected with human immunodeficiency virus (HIV) may experience this type of lipodystrophy after receiving antiretroviral therapy.. The development of lipodystrophy is related to the severity and duration of treatment.... In most cases, people with LD-HIV gradually lose fat on their arms, legs, and face, and in some of them, fat on the face, back, and neck, external pimples, bulges, and spots.. waist.

  4... Localized lipodystrophy

  This form of acquired lipodystrophy, which can occur at any age, causes fat to disappear in a small area of ​​your body. Localized lipodystrophy is like a small depression that usually does not affect the skin.

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  Symptoms of acquired lipodystrophy

  Although acquired lipodystrophy causes loss of body fat, different types can have different symptoms.

  Symptoms of acquired general lipodystrophy

  People with AGL lose subcutaneous fat all over the body, including the face, arms, legs, palms, and sometimes the soles of the feet..

  Children with AGL are always hungry and grow rapidly....If hormonal balance and continued growth are disrupted, adults may have large hands and feet, square jawbones, and larger than normal genitalia.

  Women with AGL may have irregular periods or no periods at all... They may also have polycystic ovary syndrome (PCOS) or may have extra hair on the back of their lips and chin.... Some people with this condition may have dark, velvety patches in the armpits, neck, around the navel, nipples, and on the arms. He will have problems in his body or controlling his blood sugar and triglyceride levels... In addition, there is a possibility that his liver or spleen will be enlarged.

  Symptoms of partial acquired lipodystrophy

  APL affects only the upper body on both sides of the body....The disease usually starts on the face and spreads to the neck, arms, and chest.

  Symptoms of lipodystrophy caused by highly active antiretroviral treatment

  Most people with LD-HIV gradually lose fat on their arms, legs, and face. Some may have extra fat on their face, neck, upper back, and waist.

  Symptoms of localized lipodystrophy

  In people with this type of lipodystrophy, there is a depression in the skin, but the skin itself looks normal. The size of the depression can be different and it can be in one or more different places.. There may also be sensitive or painful bumps.

  If you have such symptoms, see a nutritionist.

  The cause of acquired lipodystrophy

  Acquired lipodystrophy is caused by drugs, autoimmune reactions or unknown causes (idiopathic). Although this disease is not directly related to genetics, researchers believe that some people are genetically predisposed to it.

  Causes of acquired general lipodystrophy

  Acquired generalized lipodystrophy may occur following an infection or autoimmune disease. Infections associated with this disease include:

  • chicken pox
  • Measles
  • whooping cough
  diphtheria
  • Pneumonia
  Osteomyelitis Mononucleosis

  The following autoimmune problems may lead to generalized acquired lipodystrophy:

  • Autoimmune thyroiditis
  • Autoimmune hepatitis
  • Dematomyositis of youth
  • Rheumatism
  • Sjogren's syndrome
  • Autoimmune hemolytic anemia

  Having these infections and autoimmune diseases does not mean that you will definitely develop acquired lipodystrophy... In many cases, the cause of generalized acquired lipodystrophy is unknown.

  Causes of partial acquired lipodystrophy

  Scientists believe that acquired partial lipodystrophy is caused by the mistaken destruction of fat cells by the body's immune system... More than 80% of people with this disease have low levels of supplement C3... Supplement C3 is a protein factor that plays a role in the activity of the immune system.

  In addition, people with acquired partial lipodystrophy often have an autoantibody in their blood. An autoantibody is a protein associated with the immune system that mistakenly targets and damages healthy tissue.

  Reasons of lipodystrophy caused by highly active antiretroviral therapy

  Scientists do not know exactly why antiretroviral therapy, known as HAART, which contains HIV-1 protease inhibitors, causes lipodystrophy. Fortunately, acquired lipodystrophy is not a concern for most people currently starting HIV treatment, as the chance of developing it with newer HIV drugs is low.

  Reasons of localized lipodystrophy

  Repeated injections or constant pressure on a certain point of the body may lead to localized lipodystrophy.. For example, people with diabetes who have to inject insulin every day may suffer from this problem... That is why it is recommended to change the injection site periodically.

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  Ways to diagnose acquired lipodystrophy

  The doctor will do a thorough examination and ask you the following questions:

  • What symptoms have you observed in yourself or your child?
  • When did you first see them?
  • Are these changes only in certain areas of the body or are they everywhere?
  • Do you have panniculitis (swollen bumps under the skin or raised red rash)?
  • Do you have diabetes?
  • What disorders and injuries have you had recently?
  • Have you checked your blood sugar, cholesterol and triglyceride levels?

  Body fat testing can confirm the diagnosis....For a skin biopsy, the doctor removes a small area of ​​skin and examines the cells under a microscope....In addition, the doctor may look for a pattern of fat loss in the following ways:

  • Measuring the thickness of skin folds (checking the amount of skin that can be held between the fingers in certain parts of the body)
  • X-ray that measures bone mineral density
  • Whole body MRI which uses powerful magnets and radio waves to create images of fat tissue

  Blood test also helps to diagnose the disease.... With this test, you can measure the level of blood sugar, fats, liver enzymes and uric acid and make sure of the health of the kidneys..

  Treatment of acquired lipodystrophy

  Since you can't replace lost body fat, your goal should be to prevent complications....a healthy lifestyle plays a big role in this....all people with lipodystrophy should eat a low-fat diet....but children still need enough calories and proper nutrition to grow....exercise helps your child's health....physical activity lowers blood sugar and prevents dangerous fat accumulation.

  People with AGL may be able to use injectable metroleptin to replace lost leptin and prevent other diseases.. Statins and omega-3 fatty acids (found in some fish) are effective in controlling high cholesterol or triglycerides.. certain lipid levels.

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  Your doctor may prescribe a lotion or cream to lighten dark spots....Over-the-counter scrubs and bleaches are likely to be ineffective and can irritate the skin.

  As the child gets older, he may be able to improve his facial appearance with plastic surgery and skin grafts from the thighs, abdomen, or scalp. Doctors also use implants and fillers to help reshape parts of the face. People with APL who have excess fat deposits can use liposuction to get rid of them, but the fat may return.

  Prevention of acquired lipodystrophy disorder

  Acquired lipodystrophy is often caused by infection or autoimmune problems. Some infections, such as chicken pox and whooping cough, can be prevented by vaccination, but autoimmune problems and other infections associated with this disease cannot be prevented.

  Frequently Asked Questions

  How can I help my child with acquired lipodystrophy?
  Do whatever you can to boost his self-esteem...Try to focus on his accomplishments instead of how he looks... Get the help of a professional counselor so that the child learns how to control his emotions when facing the problems of this disease.
  What effect does lipodystrophy have on the body?
  Acquired partial lipodystrophy stops after a few years, but people who have more than acquired strophies reduce their general fats. The more serious the condition, however, the more people with the disease lead good, active lives.
  How common is lipodystrophy?
  In general, lipodystrophy is rare, but the acquired form is more common due to side effects of certain medications.
  Endword
  Acquired lipodystrophy is a rare but serious disease that has no definitive cure, but the symptoms associated with it are manageable... If you have any questions about this disease and how to treat it, you can consult the best nutritionist via video, audio or text at GCORP LLC.
  Sources: my.clevelandclinic, webmd
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