Rifampin under the brand name Keflex or Rifadin is a broad-spectrum antibiotic that is especially used to treat serious infections such as tuberculosis and a certain type of meningitis. This antibiotic is prescribed for bacterial infections and has no effect on the treatment of viral infections such as influenza and colds. It is produced by injection and has different doses that the doctor recommends based on the type and severity of the disease. In this article from GCORP LLC health magazine, join us to talk more about the use, side effects and method of taking rifampin.

What is the drug rifampin?

Rifampin or rifampicin is a type of antibiotic from the class of rifamycin drugs that is prescribed for serious bacterial infections such as tuberculosis and other respiratory infections.. This drug prevents their growth and reproduction by inhibiting the RNA polymerase enzyme dependent on DNA resistance in bacteria. creates bacteria and reduces its effectiveness.

Rifampin drug effect mechanism

Rifampicin drug is a broad-spectrum antibiotic whose mechanism of action is based on the inhibition of DNA-dependent RNA polymerase in bacteria.. By binding to the beta subunit of the RNA polymerase enzyme, this drug prevents the start of the RNA transcription process.... As a result, the bacteria is unable to produce and produce RNA messages..

It is interesting to know that bacteria can Polymerase become resistant to rifampin.. For this reason, this drug is usually not used alone and is prescribed together with other antibiotics to prevent bacterial resistance.

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Rifampin drug use

Rifampin 300 or other doses are prescribed at the doctor's discretion to treat serious bacterial infections such as tuberculosis and infections resistant to other antibiotics. This drug can also prevent the spread of meningitis agents such as Neisseria meningitidis. they use acute.. infections and unusual infections caused by it use types of mycobacterium..

Some other cases of using this medicine in special conditions are as follows:

Know more: The best medicine for intestinal and stomach infection

Rifampin 300 capsules for acne

Rifampin is not usually prescribed for the treatment of pimples and acne.... In some special cases where pimples do not respond to other treatment and have become more severe due to bacterial resistance to other antibiotics, the doctor may prescribe rifampin 300 capsules as part of the treatment regimen, considering all aspects.

Rifampin may also be considered as part of an antibiotic regimen to treat acute bacterial infections that predispose a person to secondary complications such as boils, as determined by the physician.

Learn more: Levofloxacin

Rifampin Capsules for Malt Fever

This drug may be prescribed with a dose of 150 or 300 together with other antibiotics such as doxycycline for the treatment of maltose fever (chronic brucellosis).

Rifampicin drug administration method

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The dose of rifampin should be determined by a specialist doctor based on the severity, type of disease and individual conditions.... This medicine should be taken on an empty stomach (one or two hours before a meal). It is also very important to take it with a full glass of water, unless the doctor has ordered otherwise.

The important points of using rifampin include the following:

• Take the medicine completely and according to the doctor's order until the end of the treatment period.
• Some medicines such as antacids may reduce the effectiveness of rifampin, so leave at least an hour between taking this capsule and other medicines.
• If you use rifampin syrup, shake it well and measure the syrup dose correctly.
• If you feel better after taking a few doses of the medicine, do not change the dose arbitrarily.
• Avoid stopping the drug arbitrarily, because it causes relapse or drug resistance.
• If after completing the treatment period, the symptoms of the disease do not disappear completely, do not start taking rifampin capsules again arbitrarily. If you forget to take a dose of the medicine, take the missed dose as soon as you remember... But if the next dose is close (less than four hours), you can continue to take the medicine according to the doctor's order.
• Never take 2 doses of rifampin at the same time to make up for a missed appointment.. because it not only does not increase the effectiveness of the drug, but also causes side effects...
• Injectable rifampin is for intravenous injection and should not be used as intramuscular or subcutaneous injection.
• For better effectiveness of rifampicin drug, you should take it every day at a certain time so that a constant dose of the drug remains in the body.

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Rifampin precautions and contraindications

This medicine should be used with caution in the presence of the following conditions and diseases, and it may be contraindicated in some cases:

• Pregnancy and breastfeeding
Liver and kidney problems
• porphyry
• Diabetes
• Jaundice
• alcohol abuse
• AIDS disease

It should be noted that this drug can reduce the effectiveness of birth control pills, so use other methods of contraception such as condoms while taking it.. Also, rifampin causes drowsiness and dizziness... so it's better to be more careful when doing things like driving that require full alertness.... Some doctors prescribe periodical tests during treatment with rifampin, which should be done regularly.

Learn more: Clarithromycin

Rifampin drug side effects

The most common side effects of this drug include changes in the color of urine, feces, tears, saliva, and sweat to yellow, orange, red, or brown.

Other complications of rifampin capsules include the following:

• diarrhea
• Blood in urine
• Liver dysfunction
• vision disorder
sleepiness
• Lower blood pressure
• hot flashes
• Headache and dizziness
• Abnormal tiredness
• Heartburn

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The following symptoms are serious and dangerous side effects of rifampin... After seeing any of them, take the patient to the emergency room immediately:

• Creation of white spots in the mouth or changes in vaginal secretions
• Persistent diarrhea
Abnormal abdominal pain
• Mucous or bloody stools
• Severe intestinal disease such as Clostridium difficile with severe diarrhea
• oral secretions and new fungal infections such as oral and vaginal yeast infections

Drug interactions

Drug interaction can reduce the effectiveness of this capsule or increase the possibility of side effects. Drugs that may interact with rifampin include:

• Calcium channel blockers
• Corticosteroids
Cardiac glycosides
• Quinolone antibiotics
• Housing
• Sedatives
• Antiacids
• Anticonvulsant drugs
• Anti-arrhythmic drugs
• Anticoagulant
• Azole antifungal drugs
Birth control pills or hormone replacement therapy
• Barbiturates
• Heart and blood pressure drugs
• Drugs to prevent organ transplant rejection
• Drugs for the treatment and prevention of malaria
• Diabetes pills
• Medications for mental disorders
• cancer treatment drugs
• Thyroid drugs
• HIV and AIDS drugs

Learn more: Ofloxacin tablets

Guide to see a doctor

Rifampin drug is an important and widely used antibiotic in the treatment of serious infections such as tuberculosis and a certain type of meningitis.. This drug prevents their growth and reproduction by inhibiting bacterial RNA. Do not.. resistance and side effects..

In this article from the GCORP LLC magazine, we introduced you to the use, side effects and method of taking rifampin.. If you have any questions about the way and safety of its use according to your specific conditions, you can visit the website of GCORP LLC and visit an online pulmonologist.. Face-to-face pulmonologist... See what you think.

Frequently Asked Questions

Sources: medlineplus | webmd