The best pills for irritable bowel syndrome [10 powerful drugs]

Zahra Elahi Yekta List of digestive disorders and diseases Last update: 2 weeks ago Published: 2 weeks ago No question

Awaiting review by Darmankade medical team

If you are looking for an answer Are you clear on the question "What is the best pill for irritable bowel syndrome?" You should know that everything depends on the type and severity of the symptoms. In this article from Darmankade Health Magazine we have introduced the most common pills such as Mburin for the treatment of IBS.

Table of Contents

• drugs Antispasmodic and relief of abdominal pain of irritable bowel syndrome; Mixed type (IBS-M)
• medicines Specific to IBS with diarrhea (IBS-D)

FAQ

Best pills for irritable bowel syndrome (IBS)

Irritable bowel syndrome has three main patterns:

1. Mixed type (IBS-M)
2. Constipation predominant (IBS-C)
3. Diarrhea predominant (IBS-D)

According to this, the type of drugs that patients take, It can be different:

Wrong treatment can make irritable bowel syndrome worse.

Be sure to consult a specialist before taking any medicine! The best irritable bowel syndrome doctor in Tehran

Anti-spasm drugs and relieve abdominal pain of irritable bowel syndrome; Mixed type (IBS-M)

These drugs reduce abnormal bowel contractions and are good for heartburn, spasms, bloating, and pain. The important point in IBS-M is that the type of dominant symptom and its severity should be considered over days or weeks so that other drugs such as rifaximin, loperamide or laxatives can complement the treatment if needed.

1- Mebeverine or Mebacto Tablet

Mebeverine is an intestinal antispasmodic drug that helps reduce heartburn, bloating, crampy pains and intestinal spasms. does This drug relaxes the smooth muscles of the intestine without disturbing the normal movement of the intestine; For this reason, it has fewer side effects than many antispasmodics.

Mborin is usually recommended for people with irritable bowel syndrome (IBS), especially when the patient's main complaint is spasms, heartache, bloating, pressure, or a feeling of being stuck in the flatulence. The best time to take Mebourein is also 20 minutes before meals

This drug is available in Iran under the names of Mebourein or Mebourein and is considered one of the most common options prescribed by gastroenterologists.

TitleDescriptionGeneric Name Mebeverine Hydrochloride Commercial Meborin, MbActo, despasmodic treatment category, antispasmodic, pharmaceutical form, 135 mg tablet - 200 mg slow release capsule, effective 30 minutes to 2 hours after consumption, consumption in pregnancy, group C (use only with the doctor's opinion), consumption in breastfeeding seems safe, but the data is limited. Rumored side effects are mild nausea, mild dizziness, headache. Usage tips It is better to consume before food. Who should not use Mborin?

Using Meburin is not recommended for the following people:

• People who have intestinal obstruction.
• People who have abdominal pain with fever or bleeding.
• People who have a history of drug sensitivity.
• People who have severe liver or kidney disease.

Meburin tablets are used to reduce pain, bloating and spasms caused by IBS.

2- Dicyclomine

Dicyclomine is an antispasmodic drug that relaxes the smooth muscles of the intestine. Its common uses include:

• Reducing abdominal cramping pains
• Helping to improve bloating, heartburn and intestinal spasm
• Reducing abnormal bowel movements in IBS

TitleDescriptionGeneric name Dicyclomine Brand name Dicyclomine, Dicyclogen Category Anticholinergic and anti-spasm therapy in the form of pills, syrup and ampoules. The effect starts 30 to 60 minutes after oral consumption. It is used in pregnancy. Group B (relatively safe, but only with a doctor's prescription). It is not recommended to use during breastfeeding. It may have a calming or stimulating effect on the baby. The common side effects are dry mouth, blurred vision, constipation, confusion, palpitations. Usage tips cause drowsiness and blurred vision. Be careful while driving, take with enough water. Dicyclomin tablet specifications Who should not use dicyclomine?

Contraindications to the use of dicyclomine include:

• Obstruction of the intestine or stomach and intestinal tract
• Angle-closure glaucoma (black eye)
• Myasthenia gravis or severe muscle weakness
• Severe heart or liver disorders
• Sensitivity to dicyclomine or other anticholinergics

Dicyclomine tablet effects It is faster and stronger than Mburin.

3- Hyoscyamine

Hyoscyamine is a strong antispasmodic drug from the anticholinergic group that helps reduce abnormal intestinal contractions and relieve colic and crampy pains. This drug is especially effective in patients who have IBS pains with severe spasms.

TitleDescription Generic name hyoscyamine Brand name Anaspas Therapeutic class Anticholinergic / antispasm of the intestine Pharmaceutical form Normal tablet, capsule and ampoule Onset of effect 20-30 minutes after oral intake Use in pregnancy Group C (only with doctor's opinion) Use during breastfeeding may reduce milk production; Only with the doctor's opinion, the common side effects of dry mouth, blurred vision, constipation, palpitations, consumption tips may cause drowsiness and blurred vision; It should be taken with enough water. Characteristics of Hyoscyamine tablets. Who should not use Hyoscyamine?

The following patients should not take hyoscyamine:

• Acute angle-closure glaucoma
• Intestinal or urinary tract obstruction
• Prostate enlargement with urinary retention
• Active ulcerative colitis
• Heart problems
• Hepatic and kidney diseases
• Sensitivity to hyoscyamine or other Anticholinergics

Hyoscyamine tablets are for patients who do not respond to Meborin.

Medications for IBS with Predominant Constipation (IBS-C)

People with IBS-C usually experience bloating, abdominal stiffness, and difficulty passing stools. Medicines of this group can regulate bowel movements and make the elimination process easier. In this case The shape of stool in irritable bowel syndrome is hard and lumpy

Tablets for irritable bowel syndrome must be used under the supervision of a doctor

1- Lubiprostone

Lubiprostone is a targeted drug for the treatment of IBS-C (Irritable Bowel Syndrome with Constipation prevails). By increasing liquid secretions in the intestine, this medicine makes stool movement smoother and reduces constipation. In addition, pain and bloating caused by stool obstruction or bowel pressure are also reduced.

Lubiprostone is a very effective option for patients who do not respond to fiber laxatives or other constipation treatments. The effect of the drug usually starts in the first 24 hours, and doctors gastroenterology recommend its regular use to completely improve the symptoms.

TitleDescriptionGeneric name clobiprostone Brand name Amitiza (Amitiza) Treatment category Prostonoid / Targeted laxative Pharmaceutical form Capsules The effect of about 24 hours after consumption, consumption in pregnancy, group C (only with the doctor's opinion), consumption in breastfeeding, the data is limited; With caution and doctor's opinion, the common side effects of nausea, diarrhea, headache and abdominal pain should be taken with food, regular consumption is necessary for a better effect. Characteristics of lobiprostone tablets

You don't know which tablet is suitable for irritable bowel syndrome?

Consult your doctor now. Who should not use lubiprostone?

Lobiprostone use is not recommended for the following people:

• intestinal obstruction or a history of chronic intestinal obstruction
• active diverticulitis
• sensitivity to lobiprostone
• severe liver problems
• use in children or adolescents under 18 years of age

Lobiprostone tablets have a stronger and more targeted effect than regular laxatives.

2- Linaclotide

Linaclotide is a targeted laxative and guanylate cyclase-C receptor agonist that is used to treat IBS-C. By increasing the secretion of chloride and water in the intestine, this medicine softens stool and makes it easier to pass, and is effective in reducing bloating and abdominal pain caused by constipation. C (only with the doctor's opinion) use in breastfeeding data is limited; With caution and the doctor's opinion, the reported symptoms are diarrhea, abdominal pain, bloating, and mild nausea. Use once a day, in case of severe diarrhea, discontinue use.

Contraindications to Linaclutide (Linaclotide) include:

• Age less than 18 years
• Intestinal obstruction or severe intestinal problems
• Severe liver or kidney disorders
• Linaclutide sensitivity
• Use in pregnancy and breastfeeding only with the doctor's advice

Linaclutide tablets increase the speed of bowel movements and reduce abdominal pain will be

3-Fibrous laxatives such as psyllium

Psyllium is a water-soluble fiber laxative. By absorbing water in the intestine, this fiber softens the stool and increases its volume, so it becomes easier to pass and reduces abdominal pressure and pain.

Psyllium is especially useful for people who have IBS-C or have chronic constipation, and it usually stimulates the bowel naturally better than chemical laxatives without causing dependence. , Konsyl , Metamucil , Reguloid , treatment category Fibrous myelin / Bulk-forming laxative Pharmaceutical form Powder, capsule, chewable tablet, sachet Start of effect 12-72 hours after consumption Consumption in pregnancy Group B (safe but requires a doctor's prescription) Consumption during breastfeeding is safe but requires a doctor's prescription Common side effects Bloating, mild abdominal pain Consume with sufficient amount of water or liquids; A slow start is recommended to reduce flatulence.Psyllium tablet specifications Who should not use psyllium?

Contraindications to taking psyllium tablets include:

• Intestinal or esophageal obstruction
• Swallowing disorder or difficulty in swallowing liquids
• Allergy to psyllium
• Consuming without enough water (risk of intestinal obstruction)
• Bleeding from the rectum

Psyllium tablets regulate stool volume.

Medications for IBS with Diarrhea (IBS-D)

People with IBS-D usually complain of frequent diarrhea and abdominal pain. The drugs introduced in this section help regulate bowel function and reduce diarrhea attacks. 1- Loperamide Loperamide is an anti-diarrheal drug. This drug reduces the frequency of bowel movements and improves stool consistency by reducing rapid bowel movements and increasing stool transit time.

Loperamide is very effective for patients with chronic diarrhea or diarrhea associated with IBS and helps reduce abdominal pain and anxiety caused by sudden diarrhea.

Anti-diarrheals, such as loperamide (Imodium A-D), can help control diarrhea. Bile acid binders, such as cholestyramine, colestipol, or colesevelam may also be prescribed

Drugs such as loperamide (Imodium A-D) can control diarrhea. Your doctor may also prescribe medications that block bile acids, such as cholestyramine, colestipol, or colsulam, to help reduce diarrhea. TitleDescriptionsGeneric name clopramide Brand name Imodium (Imodium) Therapeutic category Antidiarrheal / Antidiarrheal Pharmaceutical form Syrup and tablets Onset of effect about one hour after consumption Use in pregnancy group C (only with the doctor's opinion) Use in breastfeeding with caution, a small amount enters the milk Common side effects Constipation, nausea, bloating, dizziness Consume with enough water
Long-term use is not recommended. Characteristics of loperamide tablets Who should not use loperamide?

The use of loperamide is not recommended for the following people:

• Intestinal obstruction or severe digestive disorders
• Diarrhea with blood or high fever
• History of sensitivity to loperamide
• Long-term use is prohibited without a doctor's opinion.

The main use of loperamide is the treatment of sudden, short-term and acute diarrhea in adults and teenagers.

2- Rifaximin (Rifaximin)

Rifaximin is an antibiotic with broad activity on intestinal bacteria, which is used to treat IBS-D (irritable bowel syndrome with predominant diarrhea). This medication improves IBS symptoms by reducing harmful bacteria that may cause bloating, gas, and diarrhea.

Rifaximin is usually prescribed for short courses of 10-14 days, and its effects may continue even after the course of use has ended. This medicine is very useful for patients who have severe bloating and chronic diarrhea.

TitleDescriptionsGeneric name Crifaximin Brand name Zygat Therapeutic class Intestinal antibiotic / Non-absorbed antibiotic Pharmaceutical form Tablets Onset of effect 2-3 days after consumption Use in pregnancy Group C (only with doctor's opinion) Use in breastfeeding with caution; The data is limited. Common side effects are nausea, headache, flatulence, mild diarrhea. The treatment period is short; It is necessary to use it regularly and according to the doctor's prescription. Who should not use rifaximin?

If you have the following problems, you are not recommended to use rifaximin:

• Allergy to rifaximin or rifamycins
• Patients with severe liver problems
• Diarrhea with high fever or blood in the stool
• Long-term use without a doctor's opinion

Rifaximin use is suitable for people 12 years and older.

3-Eluxadoline

Eluxadoline is a targeted drug for IBS-D (irritable bowel syndrome with predominant diarrhea). By affecting the intestinal opioid receptors, this drug reduces bowel movements and controls the frequency of bowel movements and the severity of diarrhea. In addition, abdominal pain and anxiety caused by diarrhea are also reduced. Aloxadoline is effective for patients who have chronic and severe diarrhea, and regular consumption is usually recommended for long-term control of symptoms. Effect 1-2 days after consumption, consumption in pregnancy, group C (only with doctor's opinion), consumption in breastfeeding with caution; The data is limited. The common side effects are constipation, nausea, abdominal pain, dizziness. In case of severe constipation or severe abdominal pain, stop using it. Characteristics of Eloxadoline Tablets Who should not take Eloxadoline Tablets?

Contraindications to the use of eloxadoline are:

• obstructive problems of the gall bladder
• inflammation of the pancreas or pancreatitis
• severe liver problems
• chronic or severe constipation

eloxadoline is not suitable for people who abuse alcohol.

4- Alosetron

Alosetron is a targeted drug for IBS-D in women. This medicine reduces bowel movements and improves diarrhea, pain and urgency of defecation. The doctor usually prescribes alosterone for patients for whom other treatments have not been effective.

TitleDescriptionGeneric name Alosterone Brand name Lotronex (Lotronex) Treatment group 5-HT₃ receptor antagonist / Antidiarrheal Pharmaceutical form Pills Onset of effect one to four weeks after regular consumption Use in pregnancy Group C (only with doctor's opinion) Use in breastfeeding with caution; The data is limited. The common side effects are constipation, abdominal pain, bloating, and nausea. It is prescribed only under the supervision of a doctor and in special conditions of women. In case of severe constipation or severe abdominal pain, discontinue use. Characteristics of Alosterone tablets. Who should not use Alosterone?

Alosterone contraindications include:

• Intestinal obstruction or a history of severe constipation
• Pregnant women and children
• Patients for whom other treatments have not yet been effective, limited to adult women
• A history of severe liver or digestive problems

Alosterone is indicated for patients with severe and untreated IBS-D.

The best pills for male irritable bowel syndrome

There is no drug that can be definitively said to be the "best male irritable bowel syndrome pill"; Because the effectiveness of drugs depends more on the type of IBS and the health status of the person than gender. However, some drugs have been shown to work better in studies on men, such as rifaximin, loperamide, and psyllium.

A consultation with best doctor for irritable bowel will help you get the best treatment option based on your condition. In this way, the medical school can be your reliable companion; Because it simplifies the treatment process by offering the possibility of online appointment booking, telephone consultation and quick access to gastroenterologists.

The best pill for women's irritable bowel syndrome

For women, the choice of medicine depends more on the type of IBS than anything else, but Alosetron seems to be more effective than others in the treatment of irritable bowel syndrome.

The sex difference in Alosetron metabolism was statistically significant in the elderly but not in the young. A larger sex difference in metabolism in the elderly has been reported for some substrates of CYP3A4 [5, 9] and CYP2C9 [17]. Thus, the differential effect of age on the variation between men and women in alosetron metabolism may also be related to the activity of one or more enzymes. It seems that with increasing age, the activity of some liver enzymes such as CYP3A4 and CYP2C9 changes differently in men and women, and this causes the drug to be broken down at different speeds in elderly men and women.

quoted from pmc

Best pills for irritable bowel syndrome on multiple lines

There is no definitive drug treatment for irritable bowel syndrome, but By choosing the right medicine, you can control 70-80% of the symptoms. The best pill is chosen when you know what the main problem is; Because each drug targets only one part of the disease mechanism.

If spasms and abdominal pain predominate, usually Mburin or Hyoscyamine are most effective. If the problem is bacterial overgrowth (SIBO), rifaximin is a better choice. For functional constipation, drugs such as linaclotide or lubiprostone are best, while for chronic diarrhea or postprandial diarrhea, loperamide or eloxadoline are usually more effective. In women with severe and resistant symptoms, alosterone is sometimes used, although the prescription conditions are more limited.

So the best pill for irritable bowel syndrome is not a one-size-fits-all prescription; Rather, it is a targeted choice based on the type of symptoms, the severity of the disease, and the individual condition of the patient.

In this article from Darmankadeh magazine, we introduced the best pill for irritable bowel syndrome in order to increase your awareness. If you have more questions about their safety and effectiveness or how to use them, you can visit the Dharmankade website and consult the best doctors such as Gastroenterology Online Doctor. Also, the clinic has provided you with the possibility of receiving an online appointment for face-to-face consultation or online consultation by phone, text and video.

Common questions

How long is the treatment period for irritable bowel syndrome?

The treatment period for IBS is not fixed and depends on the type of symptoms and the body's response to the drug.

Is clidinium C tablets good for irritable bowel syndrome?

Can clidinium C be used to control pain? and abdominal spasm and reducing diarrhea in some IBS-D patients, but you can't use it as the main treatment.

Are probiotic pills effective for irritable bowel syndrome?

Tablets like Bio IBS have been introduced as probiotic pills for irritable bowel syndrome. But their effectiveness is not the same in all patients and they are usually prescribed as an adjunct to the main drugs.

What is Barij irritable bowel syndrome pill?

One of the most famous Barij products for irritable bowel syndrome is Gastrolit capsule, which contains ingredients such as Shirazi thyme essence. This capsule reduces abdominal pain, bloating and heartburn.

Source: nhs | mayoclinic | my.clevelandclinic

Top doctors: Dr. Ali Asghar Etemadi Fard | Doctor Alireza Rezaei

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